IN VIVO SCREENING MODELS FOR TREATMENT OF QC-RELATED DISORDERS
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United States of America Patent
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Issued Date -
Feb 28, 2013
app pub date -
Aug 10, 2012
filing date -
Aug 12, 2011
priority date (Note) -
Abandoned
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Abstract
A double transgenic non-human animal, in particular a transgenic mouse encoding Qpct proteins, which have been implicated in Qpct-related diseases, and Amyloid Precursor Protein (APP). Also provided are cells and cell lines comprising transgenes encoding for Qpct and APP. Also provided are methods and compositions for evaluating agents that affect Qpct, for use in compositions for the treatment of Qpct-related diseases.
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