BINDING DOMAINS
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United States of America Patent
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Issued Date -
Feb 21, 2013
app pub date -
Apr 19, 2011
filing date -
Apr 21, 2010
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Abstract
The invention relates to amino acid residues within an immunoglobulin light chain amino acid sequence (VL) which stabilize the monomeric state of the immunoglobulin single variable domain. In particular, but not exclusively, the invention describes a number of mutations that stabilize the monomeric state of DPK9 framework Vκ domain antibodies.
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