Methods and means for increasing resistance to cell damage
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United States of America Patent
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Issued Date -
Feb 14, 2013
app pub date -
Oct 3, 2011
filing date -
Jun 24, 2004
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Abandoned
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Abstract
Methods are provided to increase resistance to cell damage in a subject. The increase in resistance to cell damage in a subject in the subject is accomplished by decreasing activity of eEF2 kinase in the subject. The eEF2 kinase activity can be decreased by decreasing the amount of functional eEF2 kinase produced by the subject, including contacting the eEF2 kinase with a compound that inhibits phosphorylation of eEF2 kinase substrate or decreasing the amount of functional eEF2 kinase is decreased by reducing expression of a gene encoding the eEF2 kinase.
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