Processes and Compositions for Liposomal and Efficient Delivery of Gene Silencing Therapeutics
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United States of America Patent
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Issued Date -
Feb 14, 2013
app pub date -
Jun 20, 2012
filing date -
Oct 16, 2008
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Abandoned
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Abstract
Processes and compositions for liposomal delivery of therapeuticals prepared by contacting an aqueous solution of an active agent with a solution of liposome-forming components containing one or more DILA2 amino acid compounds or lipids in organic solvent to form an impinging stream. A protocol including flow rates, pH, and an incubation period are used to control formation of liposomal components for therapeutic applications. The impinging stream may be collected and incubated to prepare a liposomal formulation which encapsulates the active agent. The composition can be quenched with buffer and filtered by tangential flow and diafiltration and other means for finishing as a pharmaceutical composition.
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