VACCINE COMPRISING AN ATTENUATED PESTIVIRUS

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United States of America Patent

APP PUB NO 20130039946A1
SERIAL NO

13655278

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Abstract

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Attenuated pestiviruses, in particular attenuated BVDV, wherein at least one mutation is in the coding sequence for glycoprotein Ems and at least another mutation in the coding sequence for Npro which preferably leads to combined inactivation of the RNase activity residing in glycoprotein Ems in addition to the inactivation of the (hypothesized) immunomodulating activity residing in Npro. Methods for attenuating pestiviruses such as BVDV, nucleic acids encoding the pestiviruses, in particular BVDV, compositions and vaccines comprising the attenuated pestiviruses, in particular BVDV, of the invention.

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Patent Owner(s)

Patent OwnerAddress
BOEHRINGER INGELHEIM VETMEDICA GMBHGERMAN INGELHEIM INGELHEIM RHINELAND-PALATINATE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
EGE, Andreas Teubingen, DE 3 18
MEYER, Christiane Meunster, DE 12 77
MEYERS, Gregor Waldorfhaeslach, DE 18 112
von, FREYBURG Martina Heibronn, DE 9 107

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