Preparation of Lipid Nanoparticles

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United States of America Patent

SERIAL NO

13639628

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Abstract

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The present invention provides a process for producing lipid nanoparticles encapsulating therapeutic products, said process comprising: a) providing one or more aqueous solutions in one or more reservoirs; b) providing one or more organic solutions in one or more reservoirs, wherein one or more of the organic solutions contains a lipid and wherein one or more of the aqueous solutions and/or one or more of the organic solutions includes therapeutic products; c) mixing said one or more aqueous solutions with said one or more organic solutions in a first mixing region, wherein said first mixing region is a Multi-Inlet Vortex Mixer (MIVM), wherein said one or more aqueous solutions and said one or more organic solutions are introduced tangentially into a mixing chamber within the MIVM so as to substantially instantaneously produce a lipid nanoparticle solution containing lipid nanoparticles encapsulating therapeutic products.

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Patent Owner(s)

Patent OwnerAddress
SIRNA THERAPEUTICS INC300 THIRD STREET CAMBRIDGE MA 02142

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Burke, Paul A Boston, US 20 965
Gindy, Marian E North Wales, US 13 25
Kumar, Varun Princeton, US 46 133
Mathre, David J Skillman, US 23 116
Prud'homme, Robert K Lawrenceville, US 100 2159

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