Chimeric Polypeptides Useful in Proximal and Dynamic High-Throughput Screening Methods
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Feb 7, 2013
app pub date -
Apr 20, 2011
filing date -
Apr 20, 2010
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Abstract
The present invention provides a method of high-throughput screening (HTS) of active agents of a cell-surface G-Protein coupled receptor (GPCR) or another target receptor of interest. The method uses a non-invasive, sensitive reporting system that is proximal to the target of interest, combined with a dynamic, automated screening procedure so as to detect orthosteric ligands, such as agonists and antagonists, but is also suitable to detect allosteric or low affinity active agents of a GPCR and possibly other disease-related receptors.
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