DIPEPTIDE-BASED PRODRUG LINKERS FOR AROMATIC AMINE-CONTAINING DRUGS

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United States of America Patent

APP PUB NO 20130030359A1
SERIAL NO

13574157

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof, comprising a drug linker conjugate D-L, wherein D being a biologically active moiety containing an aromatic amine group is conjugated to one or more polymeric carriers via dipeptide-containing linkers. Such carrier-linked prodrugs achieve drug releases with therapeutically useful half-lives. The invention also relates to pharmaceutical compositions comprising said prodrugs and their use as medicaments.

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Patent Owner(s)

Patent OwnerAddress
ASCENDIS PHARMA ASDANE HELLER RUPP

International Classification(s)

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  • 2011 Application Filing Year
  • A61K Class
  • 10915 Applications Filed
  • 8360 Patents Issued To-Date
  • 76.60 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances201120122013201420152016201720182019202020212022202320240255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Rau, Harald Dossenheim, DE 112 3466
Vetter, Dirk Heidelberg, DE 51 3184

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Patent Citation Ranking

  • 2 Citation Count
  • A61K Class
  • 14.18 % this patent is cited more than
  • 12 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges93340159383591527830328862201 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +025050075010001250150017502000225025002750300032503500375040004250

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