Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions
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United States of America Patent
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Jun 25, 2019
Grant Date -
Jul 5, 2012
app pub date -
Feb 22, 2012
filing date -
Apr 14, 2008
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Abstract
Provided are combinations, compositions and kits containing a hyaluronan degrading enzyme, such as a soluble hyaluronidase, for treatment of hyaluronan-associated conditions, diseases and disorders. In one example, the products include an additional agent or treatment. Such products can be used in methods for administering the products to treat the hyaluronan-associated diseases and conditions, for example, hyaluronan-associated cancers, for example, hyaluronan-rich tumors. The methods include administration of the hyaluronan degrading enzyme composition alone or in combination with other treatments. Also provided are methods and compositions for providing sustained treatment effects in hyaluronan-associated diseases and conditions.
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