METHOD FOR PRODUCTION OF ARTIFICIAL PLURIPOTENT STEM CELL
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United States of America Patent
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Issued Date -
Jan 10, 2013
app pub date -
Feb 15, 2011
filing date -
Feb 16, 2010
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Abandoned
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Abstract
Disclosed is a method for producing an iPS cell having a very similar gene expression pattern to that of an ES cell with high efficiency. Specifically disclosed is a method for producing an artificial pluripotent stem cell (an iPS cell), which comprises the steps of: introducing a pluripotency-inducing factor comprising at least an Myc family gene or an Myc family protein into a somatic cell; and culturing the somatic cell in the presence of a sirtuin inhibitor and/or a poly-ADP ribose polymerase (PARP) inhibitor.
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