DEVICES AND METHODS FOR DETECTING SINGLE NUCLEOTIDE POLYMORPHISMS
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United States of America Patent
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Issued Date -
Jan 3, 2013
app pub date -
May 31, 2012
filing date -
Jun 30, 2011
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Abandoned
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Abstract
A device for detecting Single Nucleotide Polymorphism (SNP) and associated methods has been described. The stochastic behavior of a single-molecule probe is utilized to recognize wild type and SNP sequences in a microfluidic platform using a laser-tweezers instrument. The mechanical signal provides substantially noise free sensing with high sensitivity and the selectivity. The method has an inherent capacity to develop as a generic biosensor using other recognition elements such as aptamer for example.
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