SMOCI, TENASCIN-C AND BRAIN CANCERS
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United States of America Patent
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Issued Date -
Jan 3, 2013
app pub date -
Mar 4, 2011
filing date -
Mar 5, 2010
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Abandoned
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Abstract
The present invention relates to a method for treating brain cancer in a subject by administering to said subject a therapeutically effective amount of a modulator of the interaction between SPARC related modular calcium binding 1 (SMOC1) and tenascin-C, for example a specific antibody or a siRNA. The present invention also encompasses methods of diagnosing cancer by measuring levels of SMOC1, as well as method of targeted therapy using anti-SMOC1 or tenascin-C antibodies conjugated to therapeutic agents.
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