BCR-ABL1 SPLICE VARIANTS AND USES THEREOF
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United States of America Patent
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Issued Date -
Dec 27, 2012
app pub date -
Dec 3, 2010
filing date -
Dec 4, 2009
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Abandoned
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Abstract
The present invention is based on BCR-ABL1 splice variants which result from insertion and/or truncation of the BCR-ABL1 transcript and the finding that these variants provide resistance to kinase domain inhibitors such as imatinib, nilotinib and dasatinib.
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