GLUCOCEREBROSIDASE MULTIMERS AND USES THEREOF
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United States of America Patent
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Issued Date -
Dec 27, 2012
app pub date -
Mar 2, 2011
filing date -
Mar 2, 2010
priority date (Note) -
Abandoned
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Abstract
Multimeric protein structures comprising at least two glucocerebrosidase molecules being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and uses thereof in the treatment of Gaucher disease. The multimeric protein structures are characterized by longer-lasting activity as compared to native glucocerebrosidase both in serum and in lysosomes.
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