VON WILLEBRAND FACTOR SPECIFIC BINDING AGENTS AND USES THEREOF
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United States of America Patent
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Issued Date -
Dec 20, 2012
app pub date -
Nov 25, 2010
filing date -
Dec 1, 2009
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Abstract
The invention provides new uses, compositions and methods of administration for specific binding agents to von Wiliebrand Factor (vWF) in patients with thromboembolic disorders and in particular new combined uses with thrombolytic agents such as tissue plasminogen activator in patients with thromboembolic disorders such as e.g. ischemic stroke. Furthermore, a new group of vWF binding agents and an improved Middle Cerebral Artery Thrombosis Model in guinea pigs to study the effects of stroke such as ischemia (oxygen and glucose depriviation) and hemorrhage (bleeding), in particular hemorrhage, are provided.
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