System and Method to Improve Sequencing Accuracy of a Polymer
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United States of America Patent
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Issued Date -
Dec 6, 2012
app pub date -
Jun 29, 2012
filing date -
Feb 28, 2008
priority date (Note) -
Abandoned
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Abstract
The sequencing of individual monomers (e.g., a single nucleotide) of a polymer (e.g., DNA, RNA) is improved by reducing the motion of the polymer due to thermally-driven diffusion to reduce the spatial error in the position of the polymer within a measurement device. A major system parameter, such as average translocation velocity or measurement time, is selected based on the characteristics of the sensing system utilized, and an algorithm jointly optimizes the sequencing order error rate and the monomer identification error rate of the system.
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