Use of the Combinatorial Diversity of T-Lymphocyte Repertoire as a Prognostic Marker of Cancer
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United States of America Patent
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Issued Date -
Dec 6, 2012
app pub date -
Dec 9, 2010
filing date -
Dec 9, 2009
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Abandoned
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Abstract
The present invention relates to a method making it possible to identify the patients, from among those affected by a given solid cancer, that have increased risk of premature death. Said method is based on the ex vivo analysis of the lymphocytic diversity of the patients on the basis of a biological sample containing lymphocytes. In fact, low lymphocytic diversity is related to a poor prognosis. Specifically, it is possible to set a diversity threshold, depending on the analysis technology used and the cancer affecting the patient, beyond which the life expectancy of the patient is significantly less than that, in general, of the patients affected by the same disease.
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