SUBMICRO EMULSION OF PACLITAXEL USING STEROID COMPLEX AS INTERMEDIATE CARRIER

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United States of America Patent

APP PUB NO 20120308616A1
SERIAL NO

13505168

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Abstract

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A submicron emulsion of paclitaxel, the preparation method and the use thereof are disclosed. Said paclitaxel submicron emulsion comprises paclitaxel/steroid complex, oil for injection, water for injection, emulsifier, assistant emulsifier and isotonic agent, wherein the mole ratio of paclitaxel to steroid in the complex is 1:0.2˜4; preferably 1:0.25˜2. Said submicron emulsion is useful for the treatment for malignant tumor. The average particle diameter of the submicron emulsion is less than 400 nm and the pH Value is 3.5-6.

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Patent Owner(s)

Patent OwnerAddress
INSTITUTE OF MATARIA MEDICA CHINESE ACADEMY OF MEDICAL SCIENCES100050 NO 1 XIANNONGTAN STREET XICHENG DISTRICT BEIJING BEIJING CITY BEIJING CITY 100050

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fu, Zhaodi Beijing, CN 1 3
Guo, Ruifang Beijing, CN 4 8
Han, Rui Beijing, CN 68 58
Jin, Dujia Beijing, CN 4 8
Liu, Yuling Beijing, CN 23 57
Wang, Renyun Beijing, CN 5 12
Xia, Xuejun Beijing, CN 6 12
Zhang, Pengxiao Beijing, CN 2 7
Zhou, Cuiping Beijing, CN 6 13

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