TRANSGENIC RODENT EXPRESSING TRUNCATED DISC1
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United States of America Patent
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Issued Date -
Nov 29, 2012
app pub date -
Jul 16, 2009
filing date -
Jul 16, 2008
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Abandoned
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Abstract
The invention provides transgenic rodents, particularly mice, expressing truncated versions of the Disrupted-in-Schizophrenia-1 (DISC1) gene and showing Schizophrenia-related neural and behavioral phenotypes. The rodents of the invention have (1) a plurality of copies of a heterologous truncated Disc1 genomic DNA sequence which includes at least 1 stop codon after exon 8 such as to encode a Disc1 polypeptide truncated before exon 9; (2) 2 copies of endogenous Disc1 genomic DNA sequence encoding full length Disc1 polypeptide. Also provided are related materials and methods.
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