Cyclic Peptides As G-Protein Coupled Receptor Antagonists

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United States of America Patent

SERIAL NO

13365013

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Abstract

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The invention relates to novel cyclic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists. In preferred embodiments, the invention provides cyclic peptidic and peptidomimetic antagonists of C5a receptors, which are active against C5a receptors on polymorphonuclear leukocytes and macrophages. The compounds of the invention are both potent and selective, and are useful in the treatment of a variety of inflammatory conditions.

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Patent Owner(s)

Patent OwnerAddress
PROMICS PTY LIMITEDNEW SOUTH WALES

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fairlie, David Springwood, AU 18 69
March, Darren Banks, AU 5 20
Shiels, Ian Alexander Muirlea, AU 9 12
Taylor, Stephen Maxwell Bellbird Park, AU 17 50
Whitehouse, Michael W Holland Park W., AU 5 18

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