Detecting Protein Arginine Deiminase (PAD) Activity in Human Tissues and Sera
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United States of America Patent
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Issued Date -
Nov 22, 2012
app pub date -
May 21, 2012
filing date -
May 19, 2011
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Abstract
Methods for diagnosing disease that is characterized by an overabundance of citrullinated proteins such as colitis, rheumatoid arthritis, and/or malignant cancer in a subject are provided. The PAD protein activity level can be measured in a tissue sample (e.g., serum) of the subject and then compared to a control PAD protein activity range of a control group. A finding of an increased PAD protein activity level in the tissue sample of the subject compared to the PAD protein activity level of the control group is indicative of disease characterized by an overabundance of citrullinated proteins in the subject.
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