METAL-POLYSACCHARIDE CONJUGATES: COMPOSITIONS, SYNTHESIS AND METHODS FOR CANCER THERAPY
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United States of America Patent
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Issued Date -
Nov 1, 2012
app pub date -
Apr 10, 2012
filing date -
Jun 4, 2007
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Abandoned
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Abstract
The current disclosure, in one embodiment, includes a polysaccharide conjugate. This conjugate has a polysaccharide and at least one liner covalently bound to the polysaccharide. The conjugate also has at least one metal conjugated by said linker. According to another embodiment, the disclosure provides a method of synthesizing a polysaccharide conjugate by covalently bonding a linker to a polysaccharide to obtain an intermediate and by conjugating said intermediate to a metal to form a polysaccharide conjugate. This conjugate has a higher relaxivity, so it is suitable to be used as a contrast medium for hybrid camera.
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