MICRORNA COMPOUNDS AND METHODS FOR MODULATING MIR-21 ACTIVITY
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United States of America Patent
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Oct 25, 2012
app pub date -
Apr 25, 2012
filing date -
Apr 25, 2011
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Abstract
Described herein are compositions and methods for the inhibition of miR-21 activity. The compositions have certain nucleoside modification patterns that yield potent inhibitors of miR-21 activity. The compositions may be used to inhibit miR-21, and also to treat diseases associated with abnormal expression of miR-21, such as fibrosis and cancer.
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