CDK5 Inhibitors and Therapeutic Uses Thereof

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United States of America Patent

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13513744

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Abstract

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Natural occurring inhibitors of cyclin-dependent protein kinase 5 (Cdk5), isolated from the root of Rhodiola rosea are structurally different from the known Cdk inhibitors. They show selectivity among different Cdks and efficacy to inhibit Cdk via a mixed-type of inhibition, which should lead to less toxicity and side-effects. They are useful in preventing and treating diseases and disorders associated with aberrant Cdk5 activities, such as acute and/or chronic pain, neuropathic pain, diabetes mellitus, cancer, neurodegenerative diseases and neuropathological disorders.

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Patent Owner(s)

Patent OwnerAddress
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGYCLEAR WATER BAY KOWLOON

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fu, Guangmiao Hong Kong, CN 3 1
Fu, Wing Yu Hong Kong, CN 6 5
IP, Fanny Chui-Fun Hong Kong, CN 8 7
IP, Nancy Yuk-Yu Hong Kong, CN 21 56

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