MACROCYCLIC INHIBITORS OF SERINE PROTEASE ENZYMES

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United States of America Patent

APP PUB NO 20120270807A1
SERIAL NO

13503426

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to novel macrocyclic compounds and salts thereof that bind to and/or are inhibitors of serine protease enzymes. The present invention also relates to intermediates of these compounds, pharmaceutical compositions containing these compounds and methods of using the compounds. These compounds are useful as therapeutics for treatment and prevention of a range of disease indications including hyperproliferative disorders, in particular those characterized by tumor metastasis, inflammatory disorders, skin and tissue disorders, cardiovascular disorders, respiratory disorders and viral infections.

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Patent Owner(s)

Patent OwnerAddress
TRANZYME PHARMA INCFLEURIMONT QUÉBEC J1H 5N4

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Beaubien, Sylvie Sherbrooke, CA 13 180
Leogane, Olivier Brossard, CA 2 1
Marsault, Éric Sherbrooke, CA 12 37
Mathieu, Axel Sherbrooke, CA 4 24

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