ENTEROTOXIGENIC E. COLI FUSION PROTEIN VACCINES
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United States of America Patent
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Issued Date -
Oct 25, 2012
app pub date -
Oct 8, 2010
filing date -
Oct 9, 2009
priority date (Note) -
Abandoned
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Abstract
The disclosure relates to fusions of enterotoxigenic Escherichia coli (ETEC) polynucleotides and polypeptides. In one example, a toxiod heat-labile (LT) and heat-stable (STa) fusion is described. This fusion may include LT with a substituted amino acid at position 192, a linker, and STa with a substituted amino acid at positions 11, 12, 13, or 14. Further provided are vaccines containing the disclosed fusions. Example methods for administering to a subject the disclosed vaccines and using the fusions and vaccines to reduce or eliminate contamination of a food or water supply are additionally contemplated.
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