Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections
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United States of America Patent
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Issued Date -
Oct 18, 2012
app pub date -
Jun 6, 2012
filing date -
Jun 2, 2006
priority date (Note) -
Abandoned
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Abstract
One aspect of the present invention relates to compounds, and pharmaceutically acceptable salts and prodrugs thereof, that are useful as inhibitors of IMPDH. The invention also provides pharmaceutical compositions comprising the compounds of the invention which selectively inhibit parasitic IMPDH. In certain embodiments, the present invention relates to selective inhibition of C. parvum inosine-5′-monophosphate-dehydrogenase over human inosine-5′-monophosphate-dehydrogenase (IMPDH type I and type II). These compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
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