Engineering Fc Antibody Regions to Confer Effector Function
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United States of America Patent
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Issued Date -
Oct 18, 2012
app pub date -
May 24, 2012
filing date -
Nov 10, 2004
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Abandoned
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Abstract
The present invention relates to molecules having a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region. These modified molecules confer an effector function to a molecule, where the parent molecule does not detectably exhibit this effector function. In one embodiment, the variant Fc region binds FcγRIIIA and/or FcγRIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region. The molecules of the invention have particular utility in treatment, prevention or management of a disease or disorder, in a sub-population of patients, wherein the target antigen is expressed at low levels in the target cell population.
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