PREPARATION FOR REPAIRING CARTILAGE TISSUE, ESPECIALLY ARTICULAR CARTILAGE DEFECTS
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app pub date -
Apr 16, 2012
filing date -
Feb 26, 2003
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Abstract
Provided herein are preparations for repairing enchondral or osteochondral defects (4) by implantation, said preparations comprising a cartilage element (A) and optionally a bone element (B) which is connected to the cartilage element (A). The cartilage element (A) can contain cells during the implantation or is populated after the implantation with cells migrating from surrounding tissue. The aim is to better equip the cartilage element (A) of one such preparation for integration into the surrounding tissue and/or for an easy-to-achieve, primary stability. To this end, said cartilage element is not homogeneously embodied but has different characteristics in a peripheral and/or basal region (2, 3) to those in a central region (3). Said differing characteristics (A) relate to the structure and/or composition of the matrix used and/or to the cells established in the matrix, and are not used to prevent the migration of cells into the preparation from the surrounding tissue.
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