PHOTOCHEMICAL INTERNALIZATION METHOD
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United States of America Patent
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Issued Date -
Oct 4, 2012
app pub date -
Aug 16, 2010
filing date -
Aug 14, 2009
priority date (Note) -
Abandoned
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Abstract
The invention relates to methods of introducing drugs into cells which are located in body cavities. In particular, it provides a photosensitizing agent for use in a method of introducing a drug molecule into the cytosol of a cell located within a body cavity, said method comprising the step of contacting said cell with said photosensitizing agent and said drug molecule, and irradiating the cell with light of a wavelength effective to activate the photosensitizing agent. Such methods are particularly suitable for use in the delivery of cytotoxic drugs in the treatment of cancer, especially bladder cancer, ovarian cancer, cervical cancer, lung cancer, brain cancer, colorectal cancer and cancers of the oral and nasal cavity.
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