HEPATITIS C VIRUS VACCINE COMPOSITION
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United States of America Patent
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Issued Date -
Oct 4, 2012
app pub date -
Sep 30, 2010
filing date -
Sep 30, 2009
priority date (Note) -
Abandoned
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Abstract
A combination of an HCV antigen for inducing an antibody having the activity of inhibiting HCV infection and an optimum adjuvant is discovered, so as to provide an effective HCV vaccine composition. The hepatitis C virus vaccine composition comprises: inactivated viral particles obtained by inactivating infectious hepatitis C virus particles prepared from hepatitis C virus genome that contains sequences encoding NS3 protein, NS4A protein, NS4B protein, NS5A protein and NS5B protein derived from hepatitis C virus JFH1 strain;
- an oligonucleotide containing unmethylated CpG, according to SEQ ID NO: 5 in the sequence listing; andaluminium hydroxide.
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