STABILIZED SINGLE DOMAIN ANTIBODIES
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United States of America Patent
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Issued Date -
Oct 4, 2012
app pub date -
Mar 16, 2012
filing date -
Nov 8, 2002
priority date (Note) -
Abandoned
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Abstract
The present invention relates to heterospecific polypeptide constructs comprising at least one single domain antibody directed against a therapeutic and/or diagnostic target and at least one single domain antibody directed against a serum protein, said construct having a prolonged lifetime in biological circulatory systems. The invention further relates to methods for stabilising VHHs in biological circulatory systems.
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