TUMOR-SPECIFIC BACTERIAL PROMOTER ELEMENTS

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United States of America Patent

APP PUB NO 20120244621A1
SERIAL NO

13321777

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention relates to bacterial promoter elements which constitute or which are comprised in promoter regions and which confer tumour specificity to the promoter region activity, resulting in transcription of a transgene, which can be a heterologous or a homologous gene, which transgene is functionally arranged downstream of the promoter region at presence of a host bacterium in tumour tissue, while essentially conferring inactivity of the promoter region and no transcription at presence of the host bacterium in non-tumour tissue. Accordingly, the invention relates to bacterial promoter regions containing these tumour specific promoter elements.

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Patent Owner(s)

Patent OwnerAddress
HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBHINHOFFENSTRASSE 7 BRAUNSCHWEIG D-38124

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bartels, Sara Braunschweig, DE 2 13
Bumann, Dirk Riehen, CH 3 15
Deyneko, Igor Braunschweig, DE 1 11
Loessner, Holger Langen, DE 2 29
Weiss, Siegfried Braunschweig, DE 10 123
Westphal-Daniel, Kathrin Braunschweig, DE 2 13

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