NEUTRALIZING ANTIBODIES TO HIV-1 AND THEIR USE
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United States of America Patent
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app pub date -
Mar 23, 2012
filing date -
Sep 25, 2009
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Abstract
Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and uses of these antibodies, are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
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