METHODS OF GROWING TUMOR INFILTRATING LYMPHOCYTES IN GAS-PERMEABLE CONTAINERS

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United States of America Patent

SERIAL NO

13424646

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Abstract

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An embodiment of the invention provides a method of promoting regression of cancer in a mammal comprising obtaining a tumor tissue sample from the mammal; culturing the tumor tissue sample in a first gas permeable container containing cell medium therein; obtaining tumor infiltrating lymphocytes (TIL) from the tumor tissue sample; expanding the number of TIL in a second gas permeable container containing cell medium therein using irradiated allogeneic feeder cells and/or irradiated autologous feeder cells; and administering the expanded number of TIL to the mammal. Methods of obtaining an expanded number of TIL from a mammal for adoptive cell immunotherapy are also provided.

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Patent Owner(s)

Patent OwnerAddress
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICESOFFICE OF TECHNOLOGY TRANSFER NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE SUITE 700 MSC 7788 BETHESDA MD 20892-7788
WILSON WOLF MANUFACTURING CORPORATION33 5TH AVENUE NW SUITE 700 NEW BRIGHTON MN 55112

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dudley, Mark E Washington, US 9 1002
Jin, Jianjian Clarksburg, US 5 332
Rosenberg, Steven A Potomac, US 201 4278
Sabatino, Marianna Rockville, US 7 320
Somerville, Robert Montgomery Village, US 5 299
Stroncek, David Rockville, US 3 289
Wilson, John R New Brighton, US 170 9289

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