UROCORTIN 2 ANALOGS AND USES THEREOF
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United States of America Patent
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Issued Date -
Sep 20, 2012
app pub date -
Aug 27, 2010
filing date -
Aug 28, 2009
priority date (Note) -
Abandoned
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Abstract
Disclosed are polypeptides that are analogs of urocortin 2 that have pharmacological activity similar to urocortin 2 but have improved water solubility compared to urocortin 2, and pharmaceutical compositions of the polypeptides of the present invention. Also disclosed are polynucleotides encoding the polypeptides, and methods of treating pathophysiological states employing pharmaceutical compositions of the polypeptides and polynucleotides of the present invention. In addition, disclosed are vectors and host cells that include a nucleic acid encoding a polypeptide of the present invention, and kits that include pharmaceutical compositions of the present invention.
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