Incorporation of the B18R gene to enhance antitumor effect of virotherapy
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United States of America Patent
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Mar 15, 2012
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Mar 17, 2011
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Abstract
The present invention relates to a novel composition and method to potentiate the antitumor effect of an oncolytic virus by providing for resistance against a host's innate interferon response. Particularly, a B18R gene is incorporated into an oncolytic virus. During treatment of a host with the modified oncolytic virus, the oncolytic virus retains its phenotype, and the host's innate immune response has a minimal affect on viral replication.
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