METHOD FOR MANUFACTURING LOW MOLECULAR WEIGHT HYALURONIC ACID
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United States of America Patent
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app pub date -
Mar 13, 2012
filing date -
Sep 15, 2009
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Abstract
The present invention relates to a method for preparing low molecular weight hyaluronic acid from high molecular weight hyaluronic acid which is produced by Streptococcus sp. ID9102 (KCTC11395BP). The method of the invention for lowering a molecular weight of high molecular hyaluronic acid has a convenient process without the inconvenience of reprocessing for the removal of input materials, or requiring pH treatment, various reaction catalysts, and complicated additional treatment conditions as in a conventional method. The inventive method for lowering the molecular weight has an advantage in that according to a change of a reaction condition using activated carbon, the molecular weight of low molecular weight hyaluronic acid can be variously adjusted. The low molecular weight hyaluronic acid produced by the method of the invention can be produced in accordance with the standards of cosmetics or foods as well as medical supplies.
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