Process for triphosphate oligonucleotide synthesis

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United States of America Patent

PATENT NO 9035041
APP PUB NO 20120220761A1
SERIAL NO

13393851

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Abstract

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This invention relates to a process for preparing an oligonucleotide 5′-triphosphate. The process comprises the steps of: (a) synthesizing an oligonucleotide having a 5′ hydroxyl moiety; (b) reacting the 5′ hydroxyl moiety with a reagent of formula I:

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Patent Owner(s)

Patent OwnerAddress
ALNYLAM PHARMACEUTICALS INC675 WEST KENDALL STREET HENRI A TERMEER SQUARE CAMBRIDGE MA 02142

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Debart, Francoise Paris, FR 7 791
Manoharan, Muthiah Cambridge, US 491 18658
Morvan, Francois Paris, FR 7 596
Vasseur, Jean-Jacques Paris, FR 12 126
Zlatev, Ivan Cambridge, US 29 408

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