LIQUID PHASE SEPARATION OF PLASMID DNA ISOFORMS AND TOPOISOMERS
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United States of America Patent
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Issued Date -
Aug 30, 2012
app pub date -
Feb 22, 2012
filing date -
Feb 28, 2011
priority date (Note) -
Abandoned
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Abstract
The invention relates to the use of material comprising a carbamoyl-decorated anion-exchanger ligand wherein a cationic group (C), and a hydrogen donor group (N—H), are connected by a spacer with a length between 3 to 5 atoms, immobilized onto or embedded into a heterogeneous matrix, for the separation of isoforms, topoisomers, oligomeric and multimeric forms of plasmid DNA (pDNA).
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