CYSTATIN C AS AN ANTAGONIST OF TGF-BETA AND METHODS RELATED THERETO
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United States of America Patent
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Issued Date -
Aug 23, 2012
app pub date -
Sep 29, 2011
filing date -
Oct 15, 2003
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Abstract
Disclosed are Cystatin C (CysC) homologues, including CystC homologues that act as antagonists or inhibitors of transforming growth factor-β (TGF-β). Also disclosed are methods to identify CystC homologues that are antagonists or inhibitors of TGF-β and compositions and therapeutic methods using CystC and homologues thereof to regulate the activity of TGF-β, and TGF-β-mediated tumor malignancy and invasion and other TGF-β-mediated fibrotic or proliferative conditions and diseases.
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