CYTOLOGICAL METHODS FOR DETECTING A CONDITION SUCH AS TRANSPLANT EFFICIENCY BY RAMAN SPECTROSCOPIC IMAGING
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United States of America Patent
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Issued Date -
Aug 9, 2012
app pub date -
May 2, 2011
filing date -
Jun 9, 2005
priority date (Note) -
Abandoned
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Abstract
Raman molecular imaging (RMI) is used to detect mammalian cells of a particular phenotype. The disclosure includes the use of RMI to detect transplanted and/or grafted cells, to differentiate between normal and diseased cells or tissues, as well as in determining the grade of said cancer cells. Raman scattering data may be analyzed to determine the transplant efficiency, disease state, clinical outcome, and/or prognosis of cells or tissue. This data may be combined with visual image data to produce hybrid images which depict both a magnified view of the cellular structures and information relating to the disease state of the individual cells in the field of view. Also, RMI techniques may be combined with visual image data and validated with other detection methods to produce confirm the matter obtained by RMI.
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