METHODS AND COMPOSITIONS FOR IDENTIFYING MODULATORS OF ANTI-TETHERIN ACTIVITY TO INHIBIT PROPAGATION OF VIRUSES

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United States of America Patent

APP PUB NO 20120196760A1
SERIAL NO

13062401

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides protein constructs for detection of interaction between Tetherin and ant-Tetherin molecules. The constructs include a Tetherin sequence or a portion of a Tetherin sequence that is sufficient for cell-surface localization, and a sequence providing a detectable signal. The invention further provides methods of using such constructs to screen for substances that modulate the Tetherin-inhibiting properties of anti-Tetherins. Methods of screening for anti-viral agents, including anti-HIV agents, are provided.

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Patent Owner(s)

Patent OwnerAddress
CHILDRENS HOSPITAL LOS ANGELES4650 SUNSET BOULEVARD LOS ANGELES CA 90027

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cannon, Paula South Pasadena, US 3 0

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