Method for Preparing Mechanically Macerated Demineralized Bone Materials and Compositions Comprising the same
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Jan 28, 2011
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Jan 28, 2011
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Abstract
The present invention relates generally to methods for preparing mechanically macerated demineralized bone materials that are useful in, or as, implants having a variety of orthopedic applications. More particularly, the demineralized bone materials prepared according to the present invention comprise web-like sections that are compression- and extrusion-resistant and thus, suitable for use in, or as, bone implants or bone grafting materials. Additionally, the web-like morphology increases the surface area of the graft and thereby facilitates the rehydration of the graft, should it be freeze dried. The increased surface area also allows for increased contact with autologous growth factors. The present invention further relates to the demineralized bone materials prepared by the disclosed methods and compositions comprising the same. Methods for preparing a bone void for orthopedic applications, such as bone implants, using the demineralized bone materials or compositions thus prepared are also provided.
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