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Abstract

A semiconductor laser based intra-cavity optical micro-fluidic biosensor comprises a coupled-cavity semiconductor laser, a 2×2 coupler and a phase adjustment section on one input port of the coupler. The dominant mode of the coupled-cavity laser appears in one output port of the coupler, while the adjacent mode comes out from the other output port of the coupler. The resonant frequency interval of the sensing cavity is slightly larger or smaller than one half of that of the reference cavity. Part of the sensing cavity is the sensing section which is covered by an analyte. The refractive index change of the analyte will cause the lasing mode of the coupled cavity to switch to an adjacent mode, resulting in a π-phase change in the phase difference between the two output ports of the two resonance cavities. By applying the Vernier effect, the power ratio of the two output ports of the coupler will change and the refractive index change of the analyte can be derived. A detection limit of 10⁻⁸ RIU or smaller can be achieved.

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