RENIN INHIBITORS

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United States of America Patent

APP PUB NO 20120190701A1
SERIAL NO

13390465

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Renin inhibitors, which are spirocyclic piperidine amides, of structural formula (I) and pharmaceutical compositions thereof useful in the treatment of cardiovascular diseases and renal insufficiency. wherein n, for each instance in which it occurs, is independently 0, 1, or 2; R1 is hydrogen, C1-6-alkyl or C3-6-cycloalkyl, wherein said C1-6-alkyl or C3-6-cycloalkyl group can be independently substituted with 1-3 halogens; A is (i) a five- or six-membered saturated or unsaturated heterocyclic or carbocyclic monocyclic ring or (ii) a five- or six-membered saturated or unsaturated heterocyclic or carbocyclic ring which is fused to another five- or six-membered saturated or unsaturated heterocyclic or carbocyclic ring, V is a bond or —(C═O)—, —CH(OH)—, —CH2—or ═CH—; U is a bond or —CH2-, or for the case when V is ═CH—, U is —CH═; X is ═CH—, ═CF—, ═C(OR3)—, or —C═O—; and Y is ═CH—, ═CF—, ═N—, or for the case when X is —C═O—, Y is —N(R3)—.

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Patent Owner(s)

Patent OwnerAddress
MERCK CANADA INCKIRKLAND QC H9H 3L1

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Austin Chih-Yu San Marcos, US 29 53
Han, Yongxin Montreal, CA 117 658
Laliberte, Sebastien Saint-Lazare, CA 18 65
Larouche, Guillaume St-Jean sur Richelieu, CA 1 0
McKay, Daniel Milton, US 12 16

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