CHROMATOGRAPHIC PROCESSES AND PURIFIED COMPOUNDS THEREOF
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United States of America Patent
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Jul 12, 2012
app pub date -
Aug 9, 2010
filing date -
Aug 11, 2009
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Abstract
The present disclosure demonstrates the utility of ion pairing agents in the preparative scale of purification. More particularly, the disclosure relates to the usage of ion pairing agents in RP preparative linear chromatography enabling high purity of the desired end product. The disclosure shows that ion-pairing agents have dramatic effect on desired purity of polypeptides.
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