DEGRADABLE THERMORESPONSIVE POLY(ETHYLENE GLYCOL) ANALOGUE MATERIALS
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United States of America Patent
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Issued Date -
Jul 12, 2012
app pub date -
May 30, 2008
filing date -
May 30, 2007
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Abandoned
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Abstract
A method of developing degradable linear poly(ethylene glycol) PEG (DPEG) with multiple functioning capacities, which can be used as drug carriers for cancer cell delivery. A DPEG may be effective in targeting cancerous tumors through an enhanced permeation and retention effect (EPR). The DPEG will then degrade in the acidic extracellular fluid of solid tumors leading to fast cellular internalizations, finally degrading in the lysosome for efficient renal clearance. These may be used in conjunction with drugs and/or targeting groups. Furthermore, DPEGs are thermoresponsive, on an as needed basis, making them useful for in vivo application.
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