INHIBITION OF HISTONE ACETYLTRANSFERASES BY CTK7A AND METHODS THEREOF
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United States of America Patent
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Issued Date -
Jun 28, 2012
app pub date -
Sep 6, 2010
filing date -
Sep 7, 2009
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Abstract
The present disclosure relates to a method for inhibiting histone acetyltransferases by derivative of curcumin, particularly CTK7A. The present disclosure also relates to identification of induction of autoacetylation of p300 and its inhibition by CTK7A. The disclosure also relates to induction of NPM1 and GAPDH overexpression and corresponding hyperacetylation of histone and methods thereof.
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