Importance

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Abstract

The invention provides a flow cytometric system comprising a first sensor positioned axially to a light source; a channel comprising means for receiving a sample target and interposed between said first sensor and light source; and a second sensor placed at an angle to said first sensor adapted to sense side scattering and/or fluorescent components and said first sensor is adapted to sense a forward scattering component in response to light illuminating the sample target in said channel. In another embodiment the invention provides for a wide dynamic range sensor comprising a plurality of photodiode pixels; wherein at least one or more of said photodiode pixels are voltage biased in one or more of the following modes: photon counting, normal, linear avalanche or Geiger modes, for wide dynamic sensor range operation. By altering the reverse bias voltage, thus putting each photodiode into one of normal, avalanche or Geiger mode, the dynamic range of incident scattering and fluorescent power to which the filter cell array is sensitive to is greatly increased, thus increasing the operational sensitivity and specificity of the cytometric instrument.

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First Claim